Get Animal Models for Retinal Diseases PDF

By Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)

ISBN-10: 1607615401

ISBN-13: 9781607615408

ISBN-10: 160761541X

ISBN-13: 9781607615415

Affecting over 100 million members around the globe, retinal ailments are one of the best factors of irreversible visible impairment and blindness, and acceptable examine versions, in particular animal versions, are necessary to furthering our knowing of the etiology, pathology, and development of those endemic illnesses. In Animal versions for Retinal Diseases, well-known specialists within the box spotlight priceless innovations in addition to animal types for the renowned retinal illnesses for you to reduction within the assessment, improvement, and development of healing options. starting with an outline of the morphology of the retina, visible habit, and genetics and genomics methods for retinal examine, the e-book keeps by way of masking animal types for the study of particular human retinal ailments, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal irritation. As a quantity within the profitable Neuromethods sequence, the chapters supply authoritative reports of the main universal techniques within the field.

Vital and straightforward to take advantage of, Animal versions for Retinal Diseases serves to aid the $64000 destiny learn of ocular investigators, ophthalmologists, and neuroscientists presently delving into this attention-grabbing box of study.

Show description

By Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)

ISBN-10: 1607615401

ISBN-13: 9781607615408

ISBN-10: 160761541X

ISBN-13: 9781607615415

Affecting over 100 million members around the globe, retinal ailments are one of the best factors of irreversible visible impairment and blindness, and acceptable examine versions, in particular animal versions, are necessary to furthering our knowing of the etiology, pathology, and development of those endemic illnesses. In Animal versions for Retinal Diseases, well-known specialists within the box spotlight priceless innovations in addition to animal types for the renowned retinal illnesses for you to reduction within the assessment, improvement, and development of healing options. starting with an outline of the morphology of the retina, visible habit, and genetics and genomics methods for retinal examine, the e-book keeps by way of masking animal types for the study of particular human retinal ailments, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal irritation. As a quantity within the profitable Neuromethods sequence, the chapters supply authoritative reports of the main universal techniques within the field.

Vital and straightforward to take advantage of, Animal versions for Retinal Diseases serves to aid the $64000 destiny learn of ocular investigators, ophthalmologists, and neuroscientists presently delving into this attention-grabbing box of study.

Show description

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Second, there are many genetically defined and uniform strains of mice. It can be important to study any disease on controlled genetic backgrounds, as genotype/phenotype interactions are not confounded by differing and uncontrolled genetic interactions that may modify the phenotype (discussed below). Third, the mouse is the mammal most amenable to genetic manipulation, including the ability to carry out large-scale genetic screens. Last, in practical terms, mice are relatively inexpensive to house (compared particularly to larger mammals), and breed quickly (a gestation time of around 20 days).

Vis Neurosci 22(5):587–593 14. den Hollander AI, Heckenlively JR, van den Born LI, de Kok YJ, van der Velde-Visser SD, Kellner U, Jurklies B, van Schooneveld MJ, Blankenagel A, Rohrschneider K et al (2001) Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene. Am J Hum Genet 69(1):198–203 15.

Behav Neurosci 111: 792–800 Jacobs GH, Williams GA, Fenwick JA (2004) Influence of cone pigment coexpression on spectral sensitivity and color vision in the mouse. Vis Res 44:1615–1622 Williams GA, Jacobs GH (2007) Cone-based vision in the aging mouse. Vis Res 47: 2037–2046 Jacobs GH, Williams GA, Cahill H, Nathans J (2007) Emergence of novel color vision in mice engineered to express a human cone photopigment. Science 315(5819):1723–1725 Keller J, Strasburger H, Cerutti DT, Sabel BA (2000) Assessing spatial vision - automated measurement of the contrast-sensitivity function in the hooded rat.

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Animal Models for Retinal Diseases by Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)


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