By Praveen Ballabh MD
The sixteen articles during this factor draw at the services of the world over well-known specialists who've jointly supplied cross-cutting experiences with a large point of view at the present country of the sector. The authors have supplied succinct, updated scientific views and spotlight present controversies and destiny demanding situations. for that reason, this factor is a state of the art compendium of this advanced and fast-moving box. during the factor, the reader is inspired to procure a extra entire point of view by means of drawing connections among previous and later articles which are thematically grouped round concerns facing pathogenesis, analysis, and remedy. This factor underscores the very important significance of persevered aid to motivate and nurture collaboration between clinicians and scientists.
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Extra resources for Advances in Neonatal Neurology, An Issue of Clinics in Perinatology, 1e
B) Diffuse WMI had pronounced astrogliosis defined by immunohistochemical staining of reactive astrocytes with glial fibrillary acidic protein (GFAP; green) and a lesser population of Iba1-labeled microglia/macrophages (red) with a reactive morphology (inset). Nuclei in the inset are visualized with Hoechst 33,342 (blue). Bar in (B), 100 mm. (Lower panel) Focal necrotic WMI. (A) Representative appearance from the largest focal hyperintense (F-hyper) lesion seen on a T2-weighted image at 1 week after injury.
These lesions typically localized to subcortical white matter. Note the substantial difference in the F-hyper lesion relative to the diffuse gliotic lesions, which appears more hypointense (D-hypo). (B) A typical macroscopic necrotic lesion defined by diffuse dense staining for reactive microglia and macrophages with Iba1 (red and inset) and a paucity of GFAP-labeled astrocytes. Nuclei in the inset are visualized with Hoechst 33,342 (blue). Bar in (B), 100 mm. ([Upper panel (A, B)] Adapted from Riddle A, Dean J, Buser JR, et al.
Aarnoudse-Moens CS, Weisglas-Kuperus N, van Goudoever JB, et al. Metaanalysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics 2009;124(2):717–28. 9. Delobel-Ayoub M, Arnaud C, White-Koning M, et al. Behavioral problems and cognitive performance at 5 years of age after very preterm birth: the EPIPAGE Study. Pediatrics 2009;123(6):1485–92. 10. Anderson PJ, Doyle LW. Cognitive and educational deficits in children born extremely preterm. Semin Perinatol 2008;32(1):51–8.
Advances in Neonatal Neurology, An Issue of Clinics in Perinatology, 1e by Praveen Ballabh MD