By Hala Gali-Muhtasib
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Extra info for Advances in Cancer Therapy
Dendritic cells activate T cell responses through direct dendritic to T cell contacts. , 1998). 1 Anti-cancer therapy The importance of exosomes in cell to cell communication can be seen in their antigen presenting ability. , 2010). The immune response was due to DEXs displaying the appropriate MHC class I molecules and tumor peptides. , 2009). , 2010). Unlike current clinical cancer vaccines, exosomes are not technically vaccines as they are preventative and not therapeutic. , 2010). , 2006).
2005). , 2009). , 2009). , 2001). In many instances, this horizontal transfer may have marked biological (transforming) consequences. , 2008). g. , 2008). , 2008). , 2010). , 2009) and viewed as a mechanism of cell recruitment to the malignant process. 4 Intercellular exchange Interactions between exosomes and their target cells may depend on the specific ligandreceptor recognition events. , 2003). , 2008). Interestingly, cloaking PS by exposure of exosomes to Annexin V often obliterates their uptake by target cells.
This suggests that conditioned media from cultured cell lines could represent an interesting starting model to detect exosomal proteomic alterations, which must then be confirmed in vivo, using biological fluids from a wide cohort of patients, in order to supply a non-invasive source for biomarker discovery. , 2009). , 2009). 2 Summary Studies confirm that urinary exosome protein profiling is an important topic and may be a valuable tool for biomarker discovery in the field of urinary tract pathology.
Advances in Cancer Therapy by Hala Gali-Muhtasib